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2022 MLB Opening Day odds, picks, lines, best bets from proven model: This four-way parlay pays almost 15-1

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After a work stoppage during the offseason threatened — and eventually delayed the start of — the action, the 2022 MLB season finally begins on Thursday, with seven games from coast-to-coast. (Two other games have already been postponed because of expected weather.) Both of last season’s World Series participants, the champion Atlanta Braves and Houston Astros, are scheduled to play. Atlanta hosts the Cincinnati Reds and is a -210 moneyline favorite (risk $210 to win $100) in the latest Braves vs. Reds odds from Caesars Sportsbook, while Cincinnati is a +180 underdog. First pitch is 8:08 p.m. ET. 

Meanwhile Houston faces Shohei Ohtani and the Los Angeles Angels. Los Angeles is a -130 favorite in the latest Angels vs. Astros odds, while Houston is a +110 underdog. First pitch is 9:38 p.m. ET. Before making any MLB Opening Day picks or parlays on those games or others, be sure to check out the MLB predictions and betting advice from SportsLine’s proven computer model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB moneyline picks in 2021, returning more than $700 to $100 players. Anyone following it has seen huge returns.

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Now, the model has locked in four confident MLB best bets for Opening Day of the 2022 season. If you successfully parlay the picks, you’d be looking at a payout of almost 15-1. You can see the model’s MLB Opening Day picks only at SportsLine

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Top MLB Opening Day picks

After simulating every Opening Day game 10,000 times, the model is high on the Astros (+110) beating the Angels. Houston is coming off its third World Series appearance in the last five seasons. Meanwhile Los Angeles is coming off a 77-85 year in which it finished 18 games behind the division-winning Astros in the AL West.

The Angels start two-way sensation Ohtani on Thursday, but he has struggled against Houston in his career. In two starts against the Astros last season, Ohtani went 0-1, allowing seven runs and 13 hits in 10.1 innings pitched. For his career, he has a 6.86 ERA against Houston.

Featured Game | Los Angeles Angels vs. Houston Astros

How to make Opening Day MLB parlays

The model also locked in three other best bets for Opening Day, including a play on an even bigger road underdog than the Astros. You can only see the model’s MLB Opening Day parlay and best bets at SportsLine

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What MLB Opening Day MLB picks should you target for a payout of almost 15-1? And what road underdog does the model like on Thursday? Visit SportsLine now to see the Opening Day MLB best bets from a model coming off a 209-178 record on top-rated MLB moneyline picks in 2021, and find out.

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