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Rams vs. 49ers odds, line: 2020 NFL picks, Week 12 predictions from advanced computer model

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The San Francisco 49ers and the Los Angeles Rams are set to square off in an NFC West matchup at 4:05 p.m. ET on Sunday at SoFi Stadium. Los Angeles is 7-3 overall and 4-0 at home, while the 49ers are 4-6 overall and 3-2 on the road. The Niners won the first meeting between the teams in Week 6, 24-16. 

Los Angeles is favored by 6.5 points in the latest Rams vs. 49ers odds from William Hill Sportsbook, and the over-under is set at 44.5. Before entering any 49ers vs. Rams picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,800 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 19-10 on top-rated NFL picks this season, returning almost $800. The model also enters Week 12 on an incredible 115-75 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.


Now, the model has set its sights on Rams vs. Niners. You can head to SportsLine to see its picks. Here are several NFL betting lines for Niners vs. Rams:

  • Rams vs. 49ers spread: Rams -6.5
  • Rams vs. 49ers over-under: 44.5 points
  • Rams vs. 49ers money line: Los Angeles -300, San Francisco +250
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What you need to know about the Rams

The Rams edged the Tampa Bay Buccaneers 27-24 on Monday night. Los Angeles has won two straight games and three of its past four. Robert Woods had a team-high 12 receptions for 130 yards and a TD last week, his fifth career game with 10-plus receptions. Cooper Kupp tied his career high with 11 receptions for a team-high 145 yards last week. Kupp (64) and Woods (54) are the only pair of NFC teammates with 50-plus catches each this season.

Jared Goff passed for 376 yards and three TDs last week. He is aiming for his fourth game in a row with 300-plus yards. Goff has 13 games with 350-plus passing yards since 2017, the most in the NFL. He has 14 TDs vs. four INTs in seven career starts vs. San Francisco. Aaron Donald is tied for third in the NFL with nine sacks. He has 10.5 sacks in his past seven games vs, the 49ers. Jordan Fuller had his first two career INTs last week. Sean McVay is 4-3 vs. San Francisco.  

What you need to know about the 49ers

Meanwhile, the 49ers fell to the Saints two weeks ago, 27-13. San Francisco could not hold onto an early 10-0 lead and committed four turnovers. The Niners have lost three consecutive games. Nick Mullens threw a pair of second half interceptions when the team was in scoring range. Mullens finished with 247 passing yards, and gets a tough draw in Week 12. The Rams enter the game with only 11 passing touchdowns allowed, which is the best in the NFL.

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Deebo Samuel (hamstring) is expected to play for the first time since Week 7 on Sunday. Brandon Aiyuk (COVID-19 list) is not expected to play. Raheem Mostert (ankle) and Richard Sherman (calf) will be activated from injured reserve and are questionable for Week 12. Mostert had 76 scrimmage yards in the Week 6 meeting. The 49ers have won the last three meetings with the Rams. 

How to make Rams vs. 49ers picks

The model has simulated Rams vs. 49ers 10,000 times and the results are in. It is leaning over on the total, and it’s also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins 49ers vs. Rams? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the 49ers vs. Rams spread to jump on Sunday, all from the model that enters Week 12 of the NFL season on an incredible 115-75 roll. 

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