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Saints vs. Patriots odds, line, spread, predictions: 2021 NFL picks, Week 3 best bets from model on 122-81 run

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The NFL’s two longest-tenured coaches match wits on Sunday when Bill Belichick and the New England Patriots host Sean Payton and the New Orleans Saints in a Week 3 matchup at Gillette Stadium. Belichick, 69, has been with the Patriots since 2000 and won six Super Bowls with the franchise. New England (1-1) is coming off a 25-6 win at the Jets. Payton, 57, has led the Saints since 2006 and won Super Bowl XLIV with the franchise. New Orleans (1-1) enters Week 3 coming off an embarrassing 26-7 loss to the Carolina Panthers. Belichick leads the head-to-head series between the coaches, 2-1. 

Kickoff is 1 p.m. ET. New England is a three-point favorite in the latest Patriots vs. Saints odds from Caesars Sportsbook while the Over-Under for total points scored is 42.5. Before you lock in any Saints vs. Patriots picks, you need to see what the proven SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up almost $7,800 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 3 of the 2021 season on an incredible 122-81 run on top-rated NFL picks that dates back to the 2017 season.

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The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.


Now, the model has zeroed in on Patriots vs. Saints and locked in another confident against-the-spread pick. You can only see the model’s Patriots vs. Saints picks at SportsLine. Now, here are several Week 3 NFL odds and betting lines for Saints vs. Patriots:

  • Patriots vs. Saints spread: New England -3
  • Patriots vs. Saints Over-Under: 42.5
  • Patriots vs. Saints moneyline: New England -150, New Orleans +130 
  • NE: Patriots rank fifth in the NFL in total yards allowed per game (297.5) 
  • NO: Juwan Johnson ranks third among tight ends in TD receptions (two)

Featured Game | New England Patriots vs. New Orleans Saints

Why the Patriots can cover

New England’s defense has been solid to start the season. The Patriots are allowing just 297.5 total yards per game, which ranks fifth in the league. In Sunday’s victory against the Jets, New England recorded four interceptions, four sacks, and allowed just six points.

That defense will face a New Orleans passing offense that has struggled through the first two weeks. The Saints are averaging just 115.5 passing yards per game. That ranks last in the league and the fewest under Payton through the first two games of the season since 2007.

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Why the Saints can cover

A major reason for New Orleans’ woeful performance on Sunday against Carolina was the absence of several players and coaches, and many of those are expected to be available against the Patriots. Cornerback Marshon Lattimore (thumb), safety C.J. Gardner-Johnson and defensive end Tanoh Kpassagnon each practiced on Wednesday after missing Sunday’s game and are on track to return against New England. Also, Payton said that the 10-day window will expire soon for several coaches who were forced to sit out Sunday’s game because of COVID protocols, allowing them to return for the game.

In addition, New Orleans has played well recently as the underdog. Since the start of the 2018 season, the Saints are 9-2 straight-up when they are not favored, including a 35-point win against Green Bay in Week 1 of this season. Their 9-2 record is the best in the NFL in that span.

How to make Patriots vs. Saints picks

Now, the model has broken down Saints vs. Patriots from every angle. The model is leaning under, but its much stronger play is on the spread. The model says one side of the Saints vs. Patriots spread has all of the value. You can only see the model’s Patriots vs. Saints picks at SportsLine

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So who wins Patriots vs. Saints? And which side of the spread has all of the value? Visit SportsLine now to see which side of the Saints vs. Patriots spread you should jump on, all from the advanced model that is up almost $7,800, and find out.

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