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Thursday Night Football odds, spread, line: Cardinals vs. Saints predictions, NFL picks from expert on 8-2 run

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The Arizona Cardinals will try to snap a two-game losing streak when they take on the New Orleans Saints in a key NFC matchup on Thursday Night Football. The Cardinals (2-4), who trail NFC West tri-leaders San Francisco, Los Angeles and Seattle by one game, have lost three of four. The Saints (2-4), who trail NFC South-leading Tampa Bay and Atlanta, both 3-3, have lost four of five. This will be the first meeting between the teams since 2019, when the Saints registered a 31-9 win in New Orleans.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 8:15 p.m. ET. Arizona is a 2.5-point favorite in the latest Cardinals vs. Saints odds from Caesars Sportsbook, while the over/under for total points scored is 43.5. Before making any Saints vs. Cardinals picks, be sure to see the NFL predictions from SportsLine’s resident Cardinals expert, Tom Fornelli.

The CBS national writer went a profitable 29-16-1 in his last 46 NFL best bets. What’s more, he has demonstrated a particularly sharp eye for the Cardinals. In fact, Fornelli has gone a stunning 8-2 on NFL picks involving Arizona. Anyone who has followed him is way up.

Now, Fornelli has set his sights on Cardinals vs. Saints and just locked in his picks and NFL Week 7 predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting lines for Saints vs. Cardinals:

  • Cardinals vs. Saints spread: Arizona -2.5
  • Cardinals vs. Saints over/under: 43.5 points
  • Cardinals vs. Saints money line: New Orleans +122, Arizona -145
  • NO: Saints are 4-1 against the spread in their last five games following a straight-up loss
  • ARI: Cardinals are 15-5-1 ATS in their last 21 games in October
  • Cardinals vs. Saints picks: See picks at SportsLine

Why the Cardinals can cover

Quarterback Kyler Murray is a dual-threat and leads Arizona in passing and rushing. Murray has completed 164 of 252 passes (65.1 percent) for 1,463 yards and six touchdowns. He has been picked off four times and has a rating of 81.8. Rushing-wise, Murray has carried 38 times for 233 yards (6.1 average) and two touchdowns. He has two explosive runs of 20 or more yards, including a long of 42 yards, and converted 14 first downs.

Defensively, safety Budda Baker is the team’s top tackler with 45, including 27 solo. He has forced one fumble. Baker will be looking for his sixth game in a row on a Thursday with five or more tackles. In his last game against the Saints, he had 14 tackles and one tackle for loss. Baker’s best game was a 13-tackle performance in the season-opener against the Kansas City ChiefsSee who to back here.

Why the Saints can cover

Running back Alvin Kamara leads New Orleans in rushing, carrying 66 times for 302 yards (4.6 average). He has two explosive plays of 20 yards or more, including a 27-yarder, and has converted 13 first downs. Kamara had six catches and 124 scrimmage yards (99 rushing, 25 receiving) last week and has 390 career receptions since entering the NFL in 2017, tied with Christian McCaffrey for the third-most by a running back in his first six career seasons all-time.

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New Orleans has some injury concerns at receiver with Michael Thomas (foot) and Jarvis Landry (ankle) missing practice early in the week. Chris Olave (concussion), however, isn’t on the team’s initial injury report, so that appears to be a positive sign for his chance to return to the lineup. Utility player Taysom Hill is also a versatile threat who has rushed for five touchdowns and thrown for another this season. See who to back here.

How to make Cardinals vs. Saints picks

Fornelli has analyzed this matchup from every angles. He’s leaning Over on the total, and he’s also isolated a critical x-factor that makes one side of the spread hit hard. See what it is at SportsLine.

Who wins Saints vs. Cardinals on Thursday Night Football? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Saints vs. Cardinals spread to back, all from the expert who is 8-2 on Arizona picks, and find out.

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